Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?

ABSTRACT:

Purpose

Septic shock has been associated with microvascular alterations and these in turn with the development of organ dysfunction. Despite advances in video microscopic techniques, evaluation of microcirculation at the bedside is still limited. Venous-to-arterial carbon dioxide difference (Pv-aCO2) may be increased even when venous O2 saturation (SvO2) and cardiac output look normal, which could suggests microvascular derangements. We sought to evaluate whether Pv-aCO2 can reflect the adequacy of microvascular perfusion during the early stages of resuscitation of septic shock.

Methods

Prospective observational study including 75 patients with septic shock in a 60-bed mixed ICU. Arterial and mixed-venous blood gases and hemodynamic variables were obtained at catheter insert

SUBMITTER: Ospina-Tascon GA 

PROVIDER: S-EPMC4726723 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature