Re-evaluation of various molecular targets located on CD34⁺CD38^-Lin^- leukemia stem cells and other cell subsets in pediatric acute myeloid leukemia.

ABSTRACT: Leukemia stem cells (LSCs) are hypothesized to be capable of driving the development of leukemia, and are responsible for disease relapse. Antibody therapy targeting cell surface antigens has significantly improved the treatment outcomes of leukemia. Therefore, it is important to identify cell surface markers that are expressed on LSCs, and that are unexpressed or expressed at reduced levels on normal hematopoietic stem cells (HSCs), in order to establish novel therapeutic targets. In the present study, the immunophenotypic characteristics of cluster of differentiation (CD)34⁺CD38^-lineage (Lin)^- stem cells were analyzed, and antigen expression levels were compared with the expression of other cell components, using multicolor flow cytometry, in 54 patients

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC4726975 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature