Highly efficient preparation of sphingoid bases from glucosylceramides by chemoenzymatic method.

ABSTRACT: Sphingoid base derivatives have attracted increasing attention as promising chemotherapeutic candidates against lifestyle diseases such as diabetes and cancer. Natural sphingoid bases can be a potential resource instead of those derived by time-consuming total organic synthesis. In particular, glucosylceramides (GlcCers) in food plants are enriched sources of sphingoid bases, differing from those of animals. Several chemical methodologies to transform GlcCers to sphingoid bases have already investigated; however, these conventional methods using acid or alkaline hydrolysis are not efficient due to poor reaction yield, producing complex by-products and resulting in separation problems. In this study, an extremely efficient and practical chemoenzymatic transformation method has been develope

SUBMITTER: Gowda SG 

PROVIDER: S-EPMC4727416 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature