Association between the Cyclin D1 G870A polymorphism and the susceptibility to and prognosis of upper aerodigestive tract squamous cell carcinomas: an updated meta-analysis.

ABSTRACT:

Purpose

Several publications have investigated the association between the Cyclin D1 G to A substitution at nucleotide 870 (CCND1 G870A) polymorphism and squamous cell carcinoma (SCC) of the upper aerodigestive tract (UADT), but their conclusions still remain controversial. We conducted a meta-analysis to precisely evaluate this association.

Patients and methods

We electronically searched the Chinese National Knowledge Infrastructure, PubMed, and Embase (up to January 2015) databases for case-control studies on the association between the CCND1 G870A polymorphism and SCC of the UADT, and 23 studies were included in total.

Results

The meta-analysis results showed that there was a significant association between the CCND1 G870A polymorphism and the risk of SCC of the UA

SUBMITTER: Meng Y 

PROVIDER: S-EPMC4727518 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature