Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.

ABSTRACT:

Objective

To determine the association of the genes that encode alpha-, beta-, and gamma-synuclein (SNCA, SNCB, and SNCG, respectively) with diffuse Lewy body disease (DLBD).

Design

Case-control study. Subjects A total of 172 patients with DLBD consistent with a clinical diagnosis of Parkinson disease dementia/dementia with Lewy bodies and 350 clinically and 97 pathologically normal controls.

Interventions

Sequencing of SNCA, SNCB, and SNCG and genotyping of single-nucleotide polymorphisms performed on an Applied Biosystems capillary sequencer and a Sequenom MassArray pLEX platform, respectively. Associations were determined using chi(2) or Fisher exact tests.

Results

Initial sequencing studies of the coding regions of each gene in 89 patients with DLBD did not

SUBMITTER: Nishioka K 

PROVIDER: S-EPMC4727539 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature