Severity of malaria in relation to a complement receptor 1 polymorphism: a case-control study.

ABSTRACT:

Background

Studies on the relationship between complement receptor 1 (CR1) polymorphisms in exon 29 encoding the Knops blood group antigens (Swain-Langley (Sl) and McCoy (McC)) and outcome of clinical malaria have produced inconsistent results.

Methods

Blood samples from Ghanaian children (n = 150) aged 1-12 years with complicated and uncomplicated malaria were genotyped for the Sl and McC blood group alleles by polymerase chain reaction and restriction fragment length polymorphism. Effect of Sl and McC genotypes on the clinical outcome of malaria was evaluated using logistic regression.

Results

McCa/b genotype was significantly associated with more than two-fold increased susceptibility for severe malaria (OR = 2.31; 95% CI: 1.03-5.20, P = 0.043). However, McCb/b was

SUBMITTER: Tettey R 

PROVIDER: S-EPMC4727578 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature