Ontology highlight
ABSTRACT:
SUBMITTER: De-la-Rosa V
PROVIDER: S-EPMC4727945 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
De-la-Rosa Víctor V Suárez-Delgado Esteban E Rangel-Yescas Gisela E GE Islas León D LD
The Journal of general physiology 20160201 2
Proton channels have evolved to provide a pH regulatory mechanism, affording the extrusion of protons from the cytoplasm at all membrane potentials. Previous evidence has suggested that channel-mediated acid extrusion could significantly change the local concentration of protons in the vicinity of the channel. In this work, we directly measure the proton depletion caused by activation of Hv1 proton channels using patch-clamp fluorometry recordings from channels labeled with the Venus fluorescent ...[more]