Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years.

ABSTRACT:

Objectives

Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.

Methods

Spirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression.

Results

Early life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1

SUBMITTER: Dratva J 

PROVIDER: S-EPMC4728209 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature