The high frequency relationship: implications for torsadogenic hERG blockers.

ABSTRACT:

Background and purpose

Ventricular arrhythmias induced by human ether-a-go-go related gene (hERG; Kv 11.1 channel) blockers are a consequence of alterations in ventricular repolarisation in association with high-frequency (HF) oscillations, which act as a primary trigger; the autonomic nervous system plays a modulatory role. In the present study, we investigated the role of β1 -adrenoceptors in the HF relationship between magnitude of heart rate and QT interval changes within discrete 10 s intervals (sorted into 5 bpm heart rate increments) and its implications for torsadogenic hERG blockers.

Experimental approach

The HF relationship was studied under conditions of autonomic blockade with atenolol (β1 -adrenoceptor blocker) in the absence or presence of five hERG blockers in

SUBMITTER: Champeroux P 

PROVIDER: S-EPMC4728413 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature