Ontology highlight
ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC4728445 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nature communications 20160105
On activation, naive T cells grow in size and enter cell cycle to mount immune response. How the fundamental processes of T-cell growth and cell cycle entry are regulated is poorly understood. Here we report that DCAF1 (Ddb1-cullin4-associated-factor 1) is essential for these processes. The deletion of DCAF1 in T cells impairs their peripheral homeostasis. DCAF1 is upregulated on T-cell receptor activation and critical for activation-induced T-cell growth, cell cycle entry and proliferation. In ...[more]