Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies.

ABSTRACT: A better understanding of vitamin K's role in health and disease requires the assessment of vitamin K nutritional status in population and clinical studies. This is primarily accomplished using dietary questionnaires and/or biomarkers. Because food composition databases in the US are most complete for phylloquinone (vitamin K1, the primary form in Western diets), emphasis has been on phylloquinone intakes and associations with chronic diseases. There is growing interest in menaquinone (vitamin K2) intakes for which the food composition databases need to be expanded. Phylloquinone is commonly measured in circulation, has robust quality control schemes and changes in response to phylloquinone intake. Conversely, menaquinones are generally not detected in circulation unless large quantities a

SUBMITTER: Shea MK 

PROVIDER: S-EPMC4728622 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature