Comprehensive identification of sexually dimorphic genes in diverse cattle tissues using RNA-seq.

ABSTRACT:

Background

Molecular mechanisms associated with sexual dimorphism in cattle have not been well elucidated. Furthermore, as recent studies have implied that gene expression patterns are highly tissue specific, it is essential to investigate gene expression in a variety of tissues using RNA-seq. Here, we employed and compared two statistical methods, a simple two group test and Analysis of deviance (ANODEV), in order to investigate bovine sexually dimorphic genes in 40 RNA-seq samples distributed across two factors: sex and tissue.

Results

As a result, we detected 752 sexually dimorphic genes across tissues from two statistical approaches and identified strong tissue-specific patterns of gene expression. Additionally, significantly detected sex-related genes shared between two

SUBMITTER: Seo M 

PROVIDER: S-EPMC4728830 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature