Genomic diversity in myeloproliferative neoplasms: focus on myelofibrosis.

ABSTRACT: The classical myeloproliferative neoplasms (MPNs) are a group of clonal diseases comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF). PMF is the rarest disease sub type and has been challenging to address due to the lack of a specific genetic marker, inadequate risk identification models and a highly variable clinical course. Continuous efforts have over time, seen the inclusion of cytogenetic information in prognostic scoring models that have resulted in improved risk stratification models providing further rationale for therapeutic management. Technological advances using single nucleotide polymorphism arrays increased the detection of known and novel MPN related changes and variant detection by massively parallel sequencing provided a larg

SUBMITTER: Singh NR 

PROVIDER: S-EPMC4729085 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature