Phylogenomic exploration of the relationships between strains of Mycobacterium avium subspecies paratuberculosis.

ABSTRACT:

Background

Mycobacterium avium subspecies paratuberculosis (Map) is an infectious enteric pathogen that causes Johne's disease in livestock. Determining genetic diversity is prerequisite to understanding the epidemiology and biology of Map. We performed the first whole genome sequencing (WGS) of 141 global Map isolates that encompass the main molecular strain types currently reported. We investigated the phylogeny of the Map strains, the diversity of the genome and the limitations of commonly used genotyping methods.

Results

Single nucleotide polymorphism (SNP) and phylogenetic analyses confirmed two major lineages concordant with the former Type S and Type C designations. The Type I and Type III strain groups are subtypes of Type S, and Type B strains are a subtype of Type

SUBMITTER: Bryant JM 

PROVIDER: S-EPMC4729121 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature