Functional Impairments Mediate Association Between Clinical Fracture Risk and Type 2 Diabetes Mellitus in Older Women.

ABSTRACT:

Objectives

To examine the effect of functional impairments in older women with diabetes mellitus (DM) on incident clinical fractures.

Design

Secondary analysis of two large prospective cohort studies.

Setting

North Carolina Established Populations for Epidemiologic Studies of the Elderly (EPESE) and Women's Health Initiative (WHI) clinical trials.

Participants

EPESE included 2,704 community-dwelling women aged 65 and older; WHI clinical trials included 68,125 postmenopausal women.

Measurements

Women with DM at baseline were compared with women without in successive Cox proportional hazards models. Functional limitations were determined according to self-reported difficulties with activities of daily living (ADLs) and physical activities.

Results

T

SUBMITTER: Lee RH 

PROVIDER: S-EPMC4729209 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature