Subclinical thyroid dysfunction and fracture risk: a meta-analysis.

ABSTRACT:

Importance

Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking.

Objective

To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures.

Data sources and study selection

The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures.

Data extraction

Individual participant data were obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid function were defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH <0.45 mIU/L), and subcli

SUBMITTER: Blum MR 

PROVIDER: S-EPMC4729304 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature