TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients.

ABSTRACT:

Background

Acute kidney injury (AKI) is an important complication in surgical patients. Existing biomarkers and clinical prediction models underestimate the risk for developing AKI. We recently reported data from two trials of 728 and 408 critically ill adult patients in whom urinary TIMP2•IGFBP7 (NephroCheck, Astute Medical) was used to identify patients at risk of developing AKI. Here we report a preplanned analysis of surgical patients from both trials to assess whether urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) accurately identify surgical patients at risk of developing AKI.

Study design

We enrolled adult surgical patients at risk for AKI who were admitted to one of 39 intensive care units across Eur

SUBMITTER: Gunnerson KJ 

PROVIDER: S-EPMC4729326 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature