Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.

ABSTRACT: Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

SUBMITTER: Daniel KB 

PROVIDER: S-EPMC4729588 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature