Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study.

ABSTRACT:

Background and purpose

Exhaled carbon monoxide (CO) is associated with cardiometabolic traits, subclinical atherosclerosis, and cardiovascular disease, but its specific relations with stroke are unexplored. We related exhaled CO to magnetic resonance imaging measures of subclinical cerebrovascular disease cross-sectionally and to incident stroke/transient ischemic attack prospectively in the Framingham Offspring study.

Methods

We measured exhaled CO in 3313 participants (age 59±10 years; 53% women), and brain magnetic resonance imaging was available in 1982 individuals (age 58±10 years; 54% women). Participants were analyzed according to tertiles of exhaled CO concentration.

Results

In age- and sex-adjusted models, the highest tertile of exhaled CO was associated with

SUBMITTER: Nayor M 

PROVIDER: S-EPMC4729607 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature