Period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection.

ABSTRACT: Most metazoans undergo dynamic, circadian-regulated changes in behavior and physiology. Currently, it is unknown how circadian-regulated behavior impacts immunity against infection. Two broad categories of defense against bacterial infection are resistance, control of microbial growth, and tolerance, control of the pathogenic effects of infection. Our study of behaviorally arrhythmic Drosophila circadian period mutants identified a novel link between nutrient intake and tolerance of infection with B. cepacia, a bacterial pathogen of rising importance in hospital-acquired infections. We found that infection tolerance in wild-type animals is stimulated by acute exposure to dietary glucose and amino acids. Glucose-stimulated tolerance was induced by feeding or direct injection; injections rev

SUBMITTER: Allen VW 

PROVIDER: S-EPMC4729625 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature