Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports.

ABSTRACT:

Objective

To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors.Design Systematic review and meta-analysis.

Main outcome measures

Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia.

Data sources

Clinical study reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK drug regulators, and summary trial reports for duloxetine and fluoxetine from Eli Lilly's website.

Eligibility criteria for study selection

Double blind placebo controlled trials that contained any patient narratives or individual patient listings of harms.

Data extraction and analysis

Two researchers extracted data independently; the outcomes were meta

SUBMITTER: Sharma T 

PROVIDER: S-EPMC4729837 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature