Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima K
PROVIDER: S-EPMC4729878 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nature communications 20160108
Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling properties, including Gs-linked GPCRs. At present, the potential role of Gs-coupled GPCRs in regulating the activity of AgRP neurons remains unknown. Here we show that the activation of Gs-coupled receptors expr ...[more]