Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.

ABSTRACT:

Objective

To investigate the characteristics of Tiam1 gene expression in human cholangiocarcinoma tissues and benign bile duct tissues, and to analyze the correlations between Tiam1 gene expression and the degree of tumor differentiation, invasive and metastatic abilities. To explore the effect of targeted inhibiting Tiam1 gene expression on proliferation and migration activity of human cholangiocarcinoma cells.

Methods

Expression of Tiam1 in 83 cases of cholangiocarcinoma tissues and 25 cases of benign bile tissues was detected using immunohistochemistry. The clinical data of patients with cholangiocarcinoma were collected. The correlations between Tiam1 gene expression and the clinicopathologic features in patients with cholangiocarcinoma were analyzed. The human cholangio

SUBMITTER: Cheng W 

PROVIDER: S-EPMC4730034 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature