Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members.

ABSTRACT: Protein kinases are essential regulators of most cellular processes and are involved in the etiology and progression of multiple diseases. The cdc2-like kinases (CLKs) have been linked to various neurodegenerative disorders, metabolic regulation, and virus infection, and the kinases have been recognized as potential drug targets. Here, we have developed a screening workflow for the identification of potent CLK2 inhibitors and identified compounds with a novel chemical scaffold structure, the benzobisthiazoles, that has not been previously reported for kinase inhibitors. We propose models for binding of these compounds to CLK family proteins and key residues in CLK2 that are important for the compound interactions and the kinase activity. We identified structural elements within the benzobi

SUBMITTER: Prak K 

PROVIDER: S-EPMC4730229 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature