Ontology highlight
ABSTRACT:
SUBMITTER: Kuranaga Y
PROVIDER: S-EPMC4730315 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kuranaga Yuki Y Yamada Nami N Kashiwaya Maiko M Nakamura Moeko M Cui Lei L Kumazaki Minami M Shinohara Haruka H Sugito Nobuhiko N Taniguchi Kohei K Ito Yuko Y Nakayama Tatsushi T Uno Bunji B Itoh Akichika A Akao Yukihiro Y
International journal of molecular sciences 20160108 1
Organic gem-dihydroperoxides (DHPs) and their derived peroxides have attracted a great deal of attention as potential anti-cancer agents. However, the precise mechanism of their inhibitory effect on tumors is unknown. To determine the mechanism of the inhibitory effects of DHPs, we examined the effects of DHPs on leukemia K562 cells. As a result, certain DHPs used in this study exhibited growth-inhibitory activity according to a clear structure-activity relationship. The most potent DHP, 12AC3O, ...[more]