Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles.

ABSTRACT:

Background

A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially of great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) in biomedical research, this study was undertaken to investigate the utility of an analogous Cmap approach in ecotoxicology. Over 3500 zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) transcriptomic profiles, each associated with one of several dozen chemical treatment conditions, were compiled into three distinct collections of rank-ordered gene lists (ROGLs) by species and microarray platforms. Individual query signatures, each consisting of multiple gene probes differentially expressed in a chemical cond

SUBMITTER: Wang RL 

PROVIDER: S-EPMC4730593 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature