The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders.

ABSTRACT:

Background

Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses.

Method

Multivariate quantitative genetic analyses were conducted using data from 9577 individuals, including 3982 complete twin pairs and 1613 individuals whose co-twin was not interviewed (aged 24-37 years) from two Australian twin samples. Analyses examined the genetic correlation between alcohol dependence, nicotine dependence and cannabis abuse/dependence and the extent to which the correlations were attributable to genetic influences shared with conduct disorder.

Results

Additive genetic (a(2) = 0.48-0.65) and non-shared environmental factors

SUBMITTER: Grant JD 

PROVIDER: S-EPMC4730914 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature