Rheumatoid arthritis, anti-tumour necrosis factor treatment, and risk of squamous cell and basal cell skin cancer: cohort study based on nationwide prospectively recorded data from Sweden.

ABSTRACT:

Objective

To investigate the risk of squamous cell and basal cell skin cancer in patients with rheumatoid arthritis naive to biologic drugs, in patients starting tumour necrosis factor (TNF) inhibitor treatment, and in the general population.

Design

Population based cohort study.

Setting

Nationwide data from Sweden.

Participants

Cohort of patients with rheumatoid arthritis naive to biologics (n=46 409), cohort of patients with rheumatoid arthritis starting TNF inhibitor treatment as first biologic in 1998-2012 (n=12 558), and matched general population comparator cohort, identified through national quality of care and health registers.

Main outcome measure

Hazard ratio of first in situ or invasive squamous cell skin cancer (1998-2012) and first basal cel

SUBMITTER: Raaschou P 

PROVIDER: S-EPMC4730989 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature