Electrocardiographic Predictors of Torsadogenic Risk During Dofetilide or Sotalol Initiation: Utility of a Novel T Wave Analysis Program.

ABSTRACT:

Introduction

Initiation of class III anti-arrhythmic medications requires telemetric monitoring for ventricular arrhythmias and QT prolongation to reduce the risk of torsades de pointes (TdP). Heart rate-corrected QT interval (QTc) is an indicator of risk, however it is imperfect, and subtle abnormalities of repolarization have been linked with arrhythmogenesis.

Purpose

Identification of electrocardiographic predictors of torsadogenic risk through the application of a novel T wave analysis tool.

Methods

Among all patients admitted to Mayo Clinic for initiation of dofetilide or sotalol, we identified 13 cases who developed drug-induced TdP and 26 age and sex matched controls that did not develop TdP. The immediate pre-TdP ECG of those with TdP was compared to the last

SUBMITTER: Sugrue A 

PROVIDER: S-EPMC4731047 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature