Are Early Relapses in Advanced-Stage Ovarian Cancer Doomed to a Poor Prognosis?

ABSTRACT:

Objective

Early recurrence (ER) after completion of therapeutic regimen in advanced-stage ovarian cancer is a challenging clinical situation. Patients are perceived as invariably having a poor prognosis. We investigated the possibility of defining different prognostic subgroups and the parameters implicated in prognosis of ER patients.

Study design

We analyzed a multi-centric database of 527 FIGO stage IIIC and IV ovarian cancer patients. We defined patients relapsing within 12 months as ER and investigated using Cox logistic regression the prognostic factors in ER group. We subsequently divided ER patients into good and poor prognosis groups according to a lower or higher overall survival (OS) at 12 months after relapse and determined parameters associated to poor prognosis

SUBMITTER: Vidal F 

PROVIDER: S-EPMC4731146 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature