Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men.

ABSTRACT:

Objective

Skeletal muscle fat infiltration (known as myosteatosis) is greater in African compared with European ancestry men and may play an important role in the development of type 2 diabetes (T2D). However, prospective studies examining the magnitude of changes in myosteatosis with aging and their metabolic consequences are sparse.

Methods

Longitudinal changes in peripheral quantitative computed tomography measured calf myosteatosis [intermuscular fat (mm(2) ) and skeletal muscle density as a measure of intramuscular fat (mg/cm(3) )] were examined in 1515 Afro-Caribbean men aged 40+ years recruited without regard to their health status.

Results

During an average of 6.2 years of follow-up, an age-related increase in intermuscular fat and a decrease in skeletal muscl

SUBMITTER: Miljkovic I 

PROVIDER: S-EPMC4731257 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature