Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.

ABSTRACT: Natural products containing phosphonic or phosphinic acid functionalities often display potent biological activities with applications in medicine and agriculture. The herbicide phosphinothricin-tripeptide (PTT) was the first phosphinate natural product discovered, yet despite numerous studies, questions remain surrounding key transformations required for its biosynthesis. In particular, the enzymology required to convert phosphonoformate to carboxyphosphonoenolpyruvate and the mechanisms underlying phosphorus methylation remain poorly understood. In addition, the model for non-ribosomal peptide synthetase assembly of the intact tripeptide product has undergone numerous revisions that have yet to be experimentally tested. To further investigate the biosynthesis of this unusual natural prod

SUBMITTER: Blodgett JA 

PROVIDER: S-EPMC4731264 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature