Early leukocyte gene expression associated with age, burn size, and inhalation injury in severely burned adults.

ABSTRACT:

Background

In the patient with burn injury, older age, larger percentage of total body surface area (TBS) burned, and inhalation injury are established risk factors for death, which typically results from multisystem organ failure and sepsis, implicating burn-induced immune dysregulation as a contributory mechanism. We sought to identify early transcriptomic changes in circulating leukocytes underlying increased mortality associated with these three risk factors.

Methods

We performed a retrospective analysis of the Glue Grant database. From 2003 to 2010, 324 adults with 20% or greater TBS burned were prospectively enrolled at five US burn centers, and 112 provided blood samples within 1 week after burn. RNA was extracted from pooled leukocytes for hybridization onto Affymetr

SUBMITTER: Sood RF 

PROVIDER: S-EPMC4731271 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature