Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder.

ABSTRACT:

Objective

To investigate the association between neuromyelitis optica spectrum disorder (NMOSD) and pregnancy outcome.

Methods

An international cohort of women with aquaporin-4 antibody-positive NMOSD and ≥1 pregnancy was studied retrospectively. Multivariate logistic regression was used to investigate whether pregnancy after NMOSD onset was associated with an increased risk of miscarriage (cohort of 40 women) or preeclampsia (cohort of 57 women).

Results

Miscarriage rate was higher in pregnancies after NMOSD onset (42.9% [95% confidence interval 17.7%-71.1%] vs. 7.04% [2.33%-15.7%]). Pregnancies conceived after, or up to 3 years before, NMOSD onset had an increased odds ratio of miscarriage (7.28 [1.03-51.6] and 11.6 [1.05-128], respectively), independent of maternal

SUBMITTER: Nour MM 

PROVIDER: S-EPMC4731292 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature