Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer.

ABSTRACT:

Aim of the study

Complement factor H (CFH) has been known to inhibit the complement pathway and to contribute to tumour growth by suppressing the anti-tumour cell mediated response in cell lines from several malignancies. We examined the association of Try402His single nucleotide polymorphism in CFH gene with lung cancer and the interaction with cigarette smoking.

Material and methods

This case-control study included 80 primary lung cancer patients and 106 control subjects who were genotyped for Try402His (rs1061170) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Results

Variant genotypes (Tyr/His and His/His) were overpresented among patients compared to controls (p = 0.03, OR = 2.510, 95% CI: 1.068-5.899), and the frequenc

SUBMITTER: Ezzeldin N 

PROVIDER: S-EPMC4731447 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature