Toward precision medicine in amyotrophic lateral sclerosis.

ABSTRACT: Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual's disease. This approach is only just beginning to be considered for treating amyotrophic lateral sclerosis (ALS). The clinical and biological complexities of ALS have hindered development of effective therapeutic strategies. In this review we consider applying the key elements of precision medicine to ALS: phenotypic classification, comprehensive risk assessment, presymptomatic period detection, potential molecular pathways, disease model development, biomarker discovery and molecularly tailored interventions. Together, these would embody a precision medicine approach, which may provide strategie

SUBMITTER: Zou ZY 

PROVIDER: S-EPMC4731596 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature