Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

ABSTRACT:

Objective

For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms.

Methods

We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations.

Resul

SUBMITTER: Traylor M 

PROVIDER: S-EPMC4731688 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature