Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants.

ABSTRACT:

Objective

We investigated whether oxidative phosphorylation (OXPHOS) abnormalities were associated with lacunar stroke, hypothesizing that these would be more strongly associated in patients with multiple lacunar infarcts and leukoaraiosis (LA).

Methods

In 1,012 MRI-confirmed lacunar stroke cases and 964 age-matched controls recruited from general practice surgeries, we investigated associations between common genetic variants within the OXPHOS pathway and lacunar stroke using a permutation-based enrichment approach. Cases were phenotyped using MRI into those with multiple infarcts or LA (MLI/LA) and those with isolated lacunar infarcts (ILI) based on the number of subcortical infarcts and degree of LA, using the Fazekas grading. Using gene-level association statistics, we t

SUBMITTER: Traylor M 

PROVIDER: S-EPMC4731691 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature