The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-β signaling.

ABSTRACT: Preeclampsia (PE) is a leading cause of maternal mortality worldwide. Several studies have detected some differentially expressed microRNAs in the preeclamptic placenta, but few of the identified microRNAs demonstrated consistent findings among different research studies. In this study, high-throughput microRNA sequencing (HTS) of 9 preeclamptic and 9 normal placentas was performed. Seventeen microRNAs were identified to be up-regulated, and 8 down-regulated in preeclamptic placentas. Eight differentially expressed microRNAs except one identified in our study were determined to be consistent with at least one previous study, while sixteen were newly found. We performed qRT-PCR with independent 22 preeclamptic placentas and 20 control placentas to verify the differentially expressed microRN

SUBMITTER: Zhou X 

PROVIDER: S-EPMC4731805 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature