The contribution of Alu exons to the human proteome.

ABSTRACT:

Background

Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. The prevailing view is that exons derived from young repetitive elements, such as Alu elements, are restricted to regulatory functions and have not had adequate evolutionary time to be incorporated into stable, functional proteins.

Results

We adopt a proteotranscriptomics approach to systematically assess the contribution of Alu exons to the human proteome. Us

SUBMITTER: Lin L 

PROVIDER: S-EPMC4731929 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature