In silico analyses of heparin binding proteins expression in human periodontal tissues.

ABSTRACT:

Background

Periodontitis is described as a group of inflammatory diseases of the gingiva and supporting structures of the periodontium. The accumulation of plaque bacteria, which include putative periodontal pathogens, is known to initiate the disease but the host immune response is the major contributing factor for destruction of periodontal tissues. Proteins that bind to heparin heparin-binding protein (HBPs) play important roles in health and disease and interact with each other via networks known as 'heparin interactomes'. This study aimed at evaluating published datasets of HBPs and its role in periodontitis.

Methods

To elucidate the role of HBPs in periodontitis, bioinformatics analyses of published data was used. In silico analyses of published datasets were used to c

SUBMITTER: Lackey B 

PROVIDER: S-EPMC4731997 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature