Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules.

ABSTRACT:

Background and objectives

Although both licensed rotavirus vaccines are safe and effective, it is often not possible to complete the schedule by using the same vaccine formulation. The goal of this study was to investigate the noninferiority of the immune responses to the 2 licensed rotavirus vaccines when administered as a mixed schedule compared with administering a single vaccine formulation alone.

Methods

Randomized, multicenter, open-label study. Healthy infants (6-14 weeks of age) were randomized to receive rotavirus vaccines in 1 of 5 different schedules (2 using a single vaccine for all doses, and 3 using mixed schedules). The group receiving only the monovalent rotavirus vaccine received 2 doses of vaccine and the other 4 groups received 3 doses of vaccine. Serum fo

SUBMITTER: Libster R 

PROVIDER: S-EPMC4732359 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature