Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone.

ABSTRACT:

Objective

To assess morning stiffness in rheumatoid arthritis (RA) patients switched from immediate-release (IR) to delayed-release (DR) prednisone.

Method

Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) is a 12-week, randomized, multicentre, active-controlled study of morning stiffness that consisted of a double-blind phase and a 9-month open-label extension. Patients receiving IR prednisone with no significant improvement after the double-blind study were switched to DR prednisone. Morning stiffness duration and median absolute and relative changes in pain and global assessment were evaluated (3, 6, and 9 months).

Results

In patients switched from IR to DR prednisone (n=110), statistically significant reductions in morning stiffness occurr

SUBMITTER: Alten R 

PROVIDER: S-EPMC4732433 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature