The use of the NIS reporter gene for optimizing oncolytic virotherapy.

ABSTRACT:

Introduction

Oncolytic viruses are experimental cancer therapies being translated to the clinic. They are unique in their ability to amplify within the body, therefore requiring careful monitoring of viral replication and biodistribution. Traditional monitoring strategies fail to recapitulate the dynamic nature of oncolytic virotherapy. Consequently, clinically relevant, noninvasive, high resolution strategies are needed to effectively track virotherapy in real time.

Areas covered

The expression of the sodium iodide symporter (NIS) reporter gene is tightly coupled to viral genome replication and mediates radioisotope concentration, allowing noninvasive molecular nuclear imaging of active viral infection with high resolution. This provides insight into replication kinetics, b

SUBMITTER: Miller A 

PROVIDER: S-EPMC4732458 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature