Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts.

ABSTRACT:

Importance

Some experts suggest that serum thyrotropin levels in the upper part of the current reference range should be considered abnormal, an approach that would reclassify many individuals as having mild hypothyroidism. Health hazards associated with such thyrotropin levels are poorly documented, but conflicting evidence suggests that thyrotropin levels in the upper part of the reference range may be associated with an increased risk of coronary heart disease (CHD).

Objective

To assess the association between differences in thyroid function within the reference range and CHD risk.

Design, setting, and participants

Individual participant data analysis of 14 cohorts with baseline examinations between July 1972 and April 2002 and with median follow-up ranging from 3.

SUBMITTER: Asvold BO 

PROVIDER: S-EPMC4732559 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature