Cth2 Protein Mediates Early Adaptation of Yeast Cells to Oxidative Stress Conditions.

ABSTRACT: Cth2 is an mRNA-binding protein that participates in remodeling yeast cell metabolism in iron starvation conditions by promoting decay of the targeted molecules, in order to avoid excess iron consumption. This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present. The oxidative stress provokes a temporary increase in the levels of Cth2 (itself a member of the iron regulon). In such conditions Cth2 molecules accumulate at P bodies-like structures when the constitutive mRNA decay machinery is compromised. In addition, a null Δcth2 mutant shows defects,

SUBMITTER: Castells-Roca L 

PROVIDER: S-EPMC4732752 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature