Patterns and prognostic value of lymph node dissection for resected perihilar cholangiocarcinoma.

ABSTRACT:

Background and aim

Lymph node metastasis is a major prognostic factor for perihilar cholangiocarcinoma (PHC). However, prognostic significance of extent of node dissection, lymph node ratio (LNR), and number and location of positive nodes remain unclear. We aimed to evaluate whether node status, LNR, or number or location of positive nodes are independent factors for staging in PHC and to determine the minimum requirements for node examination.

Methods

The Surveillance, Epidemiology, and End Results database was used to identify 1116 resected PHCs from 1998 to 2008. The correlation between nodal status and survival was analyzed retrospectively.

Results

Lymph node metastasis occurred in 43.4% patients and was an independent predictor for overall survival and cancer-spe

SUBMITTER: Mao K 

PROVIDER: S-EPMC4732906 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature