Cortical Stimulation Concurrent With Skilled Motor Training Improves Forelimb Function and Enhances Motor Cortical Reorganization Following Controlled Cortical Impact.

ABSTRACT:

Background

Electrical and magnetic brain stimulation can improve motor function following stroke in humans, rats, and nonhuman primates, especially when paired with rehabilitative training (RT). Previously, we found in rodent stroke models that epidural electrical cortical stimulation (CS) of the ipsilesional motor cortex (MC) combined with motor RT enhances motor function and motor cortical plasticity. It was unknown whether CS following experimental traumatic brain injury (TBI) would have similar effects.

Objective

To test the effects of CS combined with motor training after moderate/severe TBI on behavioral outcome and motor cortical organization.

Methods

Following unilateral controlled cortical impact (CCI) over the caudal forelimb area of the MC in adult male rat

SUBMITTER: Jefferson SC 

PROVIDER: S-EPMC4732912 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature