D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia.

ABSTRACT:

Objective

To investigate whether levodopa-induced dyskinesias (LID) are associated with D3 overexpression in levodopa-treated humans with Parkinson disease (PD).

Methods

In this case-control study, we used PET with the D3-preferring radioligand [(11)C]-(+)-PHNO to estimate D2/3 receptor binding in patients with levodopa-treated PD with LID (n = 12) and without LID (n = 12), and healthy control subjects matched for age, sex, education, and mental status (n = 18).

Results

Compared to nondyskinetic patients, those with LID showed heightened [(11)C]-(+)-PHNO binding in the D3-rich globus pallidus. Both PD groups also showed higher binding than controls in the sensorimotor division of the striatum. In contrast, D2/3 binding in the ventral striatum was lower in patients wit

SUBMITTER: Payer DE 

PROVIDER: S-EPMC4733157 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature