Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation.

ABSTRACT:

Unlabelled

Blood transcriptional signatures are promising for tuberculosis (TB) diagnosis but have not been evaluated among U.S.

Patients

To be used clinically, transcriptional classifiers need reproducible accuracy in diverse populations that vary in genetic composition, disease spectrum and severity, and comorbidities. In a prospective case-control study, we identified novel transcriptional classifiers for active TB among U.S. patients and systematically compared their accuracy to classifiers from published studies. Blood samples from HIV-uninfected U.S. adults with active TB, pneumonia, or latent TB infection underwent whole-transcriptome microarray. We used support vector machines to classify disease state based on transcriptional patterns. We externally validated our cl

SUBMITTER: Walter ND 

PROVIDER: S-EPMC4733166 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature